I read “Any Way You Can”. I loved her mother’s story and think most of the information in the book is correct, but Dr. Bosworth made such a glaring error in the multiple places where she talked about the difference in energy produced in the mitochondria from sugar and fat, that I would be embarrassed to recommend her book. The two units of energy produced from glucose are not produced in the mitochondria, but rather in the cytosol in a process called glycolysis which produces two units of ATP and two molecules of pyruvate, as well as 2 NADH+. Pyruvate can then enter the mitochondria where each molecule is converted to acetyl-CoA which enters the citric acid cycle producing just as much energy as fat that has been converted into acetyl-CoA. Two units of Acetyl-CoA in the Krebs cycle produces about 20 units of ATP. Conversion of the two pyruvate molecules to two Aceyl-CoA produces 5 ATP, the two NADH+ from glycolysis can move to the mitochondria and be converted to 5 ATP. Finally you have the two ATP produced directly from glycolysis for a total of 32 units of ATP from each glucose molecule. Every two carbons from a fat molecule can make up one acetyl-CoA, each acetyl-CoA produces 10 ATP. A 16 carbon chain fat can make 8 acetyl-CoA and produce 80 units of ATP, so fat is able to produce more energy, the numbers in the book are completely wrong. I don’t know how she got this so mixed up, but it might be because cancer cancer cells typically only use the cytosol glycolysis process, which she correctly identified as the Warburg effect. That produces only two units of ATP, because all the other ATP production takes place in the mitochondria and cancer cells typically do not have functioning mitochondria. I hope she can correct this in a revision to the book to make the book more credible.
Major mistake on information regarding energy produced from sugar
Published13 Apr 2020