As a physician dedicated to optimizing patient outcomes, I’ve witnessed firsthand how these medications are reshaping our approach to metabolic health.

Initially, I viewed GLP-1 medications with skepticism, seeing them as a temporary fix. Early patients reminded me of gastric bypass cases—marked by muscle loss and excess skin, with little evidence of the regenerative benefits I’d seen with ketogenic diets.

My first experience prescribing a GLP-1 in 2013 for advanced diabetics yielded underwhelming results. But as a scientist, I hold firm to principles while staying open to new evidence. Recent insights have shifted my stance dramatically.

In the fall of 2024, phase 2 trials unveiled a stunning possibility: GLP-1 medications may offer neuro-protective benefits, potentially even reversing Alzheimer’s disease. Derived from the saliva of the Gila monster, these drugs are far more than weight-loss tools—they influence multiple physiological systems, making them a game-changer for metabolic health. At a December 2024 conference, I learned that many insulin-resistant patients have virtually no circulating GLP-1, and a ketogenic diet can jumpstart its natural production.

This revelation inspired a new approach in our flagship program, the 21-Day Metabolic Kick Class. Here, we guide 200 students through a rigorous ketogenic diet to reset their metabolic health. At the program’s end, we began offering micro-doses of GLP-1 medications for up to three months. The results? Enhanced hormone priming, suppressed food cravings, and a powerful boost to the body’s natural systems—all at a fraction of standard doses with minimal side effects.

A common question arises:

“Will I become dependent on GLP-1?”

Our experience says no. 

When paired with a ketogenic diet and robust support, patients successfully taper off the medication while sustaining their gains. Micro-dosing acts as a catalyst, encouraging the body to produce its own GLP-1, rather than a lifelong crutch.

By 10 days into treatment, we see significant reductions in “food noise”—a sign of the medication’s broader neuro-protective effects, an area close to my heart after 25 years of tackling chronic brain illnesses.

GLP-1 medications are powerful, but they’re not a cure-all. Success hinges on education and support—tools to live beyond food-centric habits. In our latest class, over half of the 200 students opted into this experiment, though we could only accommodate 90. Their outcomes are teaching us invaluable lessons about combining ketosis, GLP-1, and community for lasting change.

Stay tuned over the next two weeks as we dive deeper into the science and share student success stories that highlight this innovative approach.

Remember to tune in for my live on Tuesday on YouTube at 4pm EST.

Improving your health, one ketone at a time,

Dr. Boz

Annette Bosworth, M.D.